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Promethazine is metabolized from the liver to various compounds; the sulfoxides of promethazine and N-demethylpromethazine would be the predominant metabolites showing within the urine.

A likely fatal symptom advanced in some cases often called Neuroleptic Malignant Syndrome (NMS) continues to be reported in association with promethazine HCl alone or together with antipsychotic prescription drugs.

Antihistamines and codeine are both equally contraindicated for use during the treatment of decrease respiratory tract signs, which include asthma.

Pregnancy Assessments: Diagnostic pregnancy tests determined by immunological reactions in between HCG and anti-HCG may perhaps end in Phony-adverse or Wrong-positive interpretations.

Promethazine HCl Oral Option need to be made use of cautiously in folks with heart problems or with impairment of liver purpose.

Head Damage And Amplified Intracranial Force: The respiratory-depressant consequences of narcotic analgesics and their capability to elevate cerebrospinal fluid tension might be markedly exaggerated during the existence of head injuries, intracranial lesions or a preexisting rise in intracranial tension.

Promethazine HCl happens as a white to faint yellow, basically odorless, crystalline powder which gradually oxidizes and turns blue on extended exposure to air. It is freely soluble in water and soluble in Liquor.

Signs and signs and symptoms of overdosage with promethazine HCl range from moderate melancholy in the central nervous system and cardiovascular procedure to profound hypotension, respiratory depression, unconsciousness, and unexpected Demise.

Promethazine HCl Oral Solution needs to be employed for the duration of pregnancy provided that the probable gain justifies the probable hazard into the fetus.

Codeine is thought to become subject to abuse; having said that, the abuse prospective of oral codeine seems being fairly reduced. Even parenteral codeine doesn't seem to supply the psychic consequences sought by addicts to a similar degree as heroin or morphine.

Regular Grownup dosage is 50 mg Promethazine HCl Oral Resolution by having an correctly decreased dose of narcotic or barbiturate along with the needed level of a belladonna alkaloid.

Concomitant administration of Promethazine merchandise with other respiratory depressants has an association with respiratory melancholy, and in some cases Dying, in pediatric individuals.

The average effective dose of Promethazine HCl Oral Solution to the click here Lively therapy of nausea and vomiting in small children or Grown ups is twenty five mg.

Promethazine Signals and symptoms of overdosage with promethazine range from gentle despair in the central nervous system and cardiovascular process to profound hypotension, respiratory depression, unconsciousness and sudden Loss of life.